On March 17, 2026, Senti Biosciences, Inc. announced a significant amendment to its existing lease agreement with 1430 South Loop Owner, LLC. The First Amendment to Lease reduces the leased premises from approximately 91,910 rentable square feet to about 45,955 rentable square feet, effective September 1, 2025. This reduction in space is accompanied by a corresponding decrease in monthly base rent, which will be adjusted over the next several years. The new rent structure includes a base rent of $188,311 from September 1, 2025, through July 31, 2026, gradually increasing to $293,010 by August 1, 2032. Additionally, the company’s share of operating expenses and taxes has been reduced to 50%, although it will continue to bear full responsibility for utilities until the surrendered space is re-leased. As part of this amendment, the landlord is entitled to draw $2.0 million from the company’s existing letter of credit as consideration for the rent reduction, which will subsequently lower the required letter of credit amount for the remainder of the lease term to $760,000. Furthermore, the company entered into a First Amendment to Sublease with GeneFab, LLC, which aligns the subleased premises and financial obligations with the amended lease terms. This strategic move is expected to enhance operational efficiency and reduce overhead costs, positioning Senti Biosciences for better financial health moving forward.

Press Release distribution

National Press Distribution across U.S. Media. Direct Access to Key Decision Making Editors.